Liquid chromatography

Improving HPLC instrument robustness through flow control and machine diagnostics

Detection of different types of molecules in a liquid mixture is a key step in various processes, ranging from pharmaceutical drug development to food production. High-performance liquid chromatography (HPLC) is one of the most effective methods for such applications, providing fast, precise and versatile operation. 

 

In the course of HPLC procedures, ensuring the precise mixing of the mobile phase and the sample is essential. This task becomes particularly challenging in cases of pump leakage or high-pressure conditions within the column. Additionally, the gradual wear of valves and pumps over time poses a threat to the instrument’s overall health, leading to unforeseen downtime and the loss of valuable samples.

How our sensors make a difference

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Optimized mixing performance

Our sensors offer high repeatability, fast response time and accurate flow monitoring to ensure the right volumes are mixed. Flows ranging from nanoliters up to milliliters/min can be identified under a pressure of up to 1,600 bar.

Controlling pump through feedback

Detecting pump leakages on the order of nanoliters to microliters allows a signal to be sent to the pump to modify its operation and ensure that the actual flow matches the desired one.

Analytical insights into your instrument

 

Relying on microthermal technology, Sensirion sensors offer a highly repeatable flow measurement down to nanoliters per minute and have been used in a variety of analytical laboratory instruments for applications such as liquid handling and pump feedback control.

 

However, our sensors can do more. On top of flow monitoring, their high sensitivity and fast reaction time enable insights into the instrument’s health and condition by detecting valve ringing, backflow, mechanical wear and bubbles.
 

 

Learn more.

Discover related sensors

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Innovation pioneer

With over 25 years of experience in flow sensing, we are aware of many challenges and know how to overcome them. Sensirion offers highly customizable solutions with various choices of materials, communication interfaces, fluidic designs and other specifications.

Why Sensirion should be part of your solution

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With over 25 years of experience in flow sensing, we are aware of many challenges and know how to overcome them. Sensirion offers highly customizable solutions with various choices of materials, communication interfaces, fluidic designs and other specifications.

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We offer a wide and growing range of products with more than 10 product lines meeting the needs of our customers in the life sciences and analytical instruments.

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Our sensor solutions are produced in Europe at competitive prices through a robust supply chain and with short lead times. In addition, a broad sales network with over 200 distribution partners worldwide supports you.

Further applications

Want more detailed information?

Download our onepager on high performance liquid chromatography (HPLC) - sensing for instrument diagnostics and flow control for free.

Want more detailed information?

Download our onepager on high performance liquid chromatography (HPLC) - sensing for instrument diagnostics and flow control for free.

HPLC onepager